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Space Physiology Research Projects
Risk of Intervertebral Disc Damage After Prolonged Space Flight Purpose: Microgravity significantly reduces normal spinal compression and the diurnal loading cycle, increasing the risk of disc prolapse or herniation when returning to a gravitational environment. Long term (6 months) microgravity exposure may also have adverse effects that can ultimately weaken disc tissues. The purpose of this study is to address and quantify the physiological changes occurring in the spine after prolonged space flight to help reduce the incidences of disc damage. Hypothesis: We hypothesize that microgravity effects biological patho-mechanisms, which ultimately result in altered disc cell metabolism as well as pain and potential disc degradation. Technologies Used: Standard and upright MRI, Spinal kinematics Fluid Distribution Before, During and After Long Duration Space Flight Purpose: Over 30% of American astronauts have developed ocular refraction change after long duration space flight on the International Space Station (ISS). Other findings have shown structural changes of the eye, as well as elevated intracranial pressure (ICP) via lumbar puncture data. These physiological changes are thought to be due space-flight induced cephalad fluid shifts and transiently elevated ICP. The fluid distribution patterns and their effects on intracranial pressure or the structure and function of the sensory organs in the course of long-duration space flight are not well known. The purpose of the proposed work is to objectively characterize the changes in fluid distribution, including intra/extracellular and intra/extravascular fluid shifts, by applying advanced non-invasive assessment technologies before, during and after long duration space flight. Hypothesis: We hypothesize the symptoms (ex: headaches, nasal congestion, altered vision, increased intracranial pressure) experienced by the crew members could be due to the cephalad fluid shifts. Technologies Used: Lower body negative pressure and Standard and upright MRI Fluid Shifts with Head Down Tilt and Lower Body Negative Pressure Purpose: Simulated microgravity and long duration flights induce a head-ward fluid shift which results in facial puffiness, nasal congestion, headache and decrease in calf circumference. Although it is known that in reduced gravity, fluid shifts from the lower extremities to the head, the mechanism is poorly understood. In this study we will use non-invasive techniques to measure changes in tissue oxygenation/ deoxygenation and the blood perfusion levels in human skin (head, arms, legs) and underlying tissues (Muscle, bone). A tilt table will be used to perform head-down whole body tilt followed by application of add-on lower body negative pressure. Hypothesis:  We hypothesize that use of lower body negative pressure (LBNP), will counteract simulated microgravity (head-down-tilt) induced changes in head and legs. The changes in tissue oxygenation and skin along with bone blood flow will provide data to determine how regulation of tissue blood flow functions in spaceflight. Technologies used: NIRS, PPG, ultrasound technology, LBNP chamber
RESEARCH Sports Medicine Tissue Pressure Microvascular Flow
Space Physiology