Clinical Physiology Laboratory In the Department of Orthopaedic Surgery
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Recent Selected Publications
2017 Siamwala JH, Macias BR, Lee PC, Hargens AR. Gender differences in tibial microvascular flow responses to head down tilt and lower body negative pressure. Physiological Reports Feb;5(4), 2017. 2016 Schneider SM, Lee SM, Feiveson AH, Watenpaugh DE, Macias BR, Hargens AR. Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest. Physiological Reports 4: 1-14, Aug;4(15), 2016. Chang DG, Healey RM, Snyder AJ, Sayson JV, Macias BR, Coughlin DG, Bailey JF, Parazynski SE, Lotz JC, Hargens AR. Lumbar paraspinal muscle and intervertebral disc height changes in astronauts after long-duration spaceflight on the International Space Station.” Spine (Phila Pa 1976).  Dec 15;41(24):1917-1924, 2016. Hargens AR and Vico L. Long-duration bed rest as an analog to microgravity. Journal of Applied Physiology (1985). Apr 15;120(8):891-903, 2016. Holt JA, Macias BR, Schneider SM, Watenpaugh DE, Lee SM, Chang DG, and Hargens AR. WISE 2005: Aerobic and resistive countermeasures prevent paraspinal muscle deconditioning during 60-days bed rest in women. Journal of Applied Physiology (1985). May 15;120(10):1215-22, 2016. Laws CJ, Berg-Johansen B, Hargens AR, and Lotz JC. The effect of simulated microgravity on lumbar spine biomechanics: an in vitro study. European Spine Journal. Sep;25(9):2889-97, 2016. Belavy DL, Adams M, Brisby H, Cagnie B, Danneels L, Fairbank J, Hargens AR, Judex S, Scheuring RA, Sovelius R, Urban J, van Dieën JH, and Wilke HJ. Disc herniations in astronauts: What causes them, and what does it tell us about herniation on Earth? European Spine Journal. Jan 25 (1):144-154, 2016. Berg-Johansen B, Liebenberg EC, Li A, Macias BR, Hargens AR, and Lotz JC. Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments. Journal of Orthopaedic Research. Jan 34(1):48-57, 2016.  2015 Siamwala JH, Lee PC, Macias BR, Hargens AR. Lower Body Negative Pressure Restores Leg Bone Microvascular Flow to Supine Levels during Head Down Tilt. J Appl Physiol (1985). Apr 30, 2015.    Belavy DL, Adams M, Brisby H, Cagnie B, Danneels L, Fairbank J, Hargens AR, Judex S, Scheuring RA, Sovelius R, Urban J, van Dieën JH, Wilke HJ. Disc herniations in astronauts: What causes them, and what does it tell us about herniation on Earth? Eur Spine J. Apr 18, 2015. Macias BR, Liu JH, Grande-Gutierrez N, Hargens AR. Intraocular and intracranial pressures during head-down tilt with lower body negative pressure.  Aerosp Med Hum Perform. Jan;86(1):3-7, 2015. Sayson JV, Lotz JC, Parazynski SE, Chang DG, Healey RM, Hargens AR. Microgravity-Induced Back Pain and Intervertebral Disc Herniation: International Space Station Results, 66th International Astronautical Congress, Jerusalem, October 2015. Mao CP, Macias BR, and Hargens AR. Shoulder skin and muscle hemodynamics during backpack carriage. Applied Ergonomics. Nov 51:80-84, 2015. 2014 Schmid-Schonbein GW and AR Hargens. “Mechanics of Tissue/Lymphatic Transport.” In: The Biomedical Engineering Handbook, 4th Edition, Biomedical Engineering Fundamentals, edited by JD Bronzino, Boca Raton, Florida: CRC Press LLC, in press, 2014. Tanaka K, P Webb and AR Hargens. “Development and Evaluation of Mechanical Counter Pressure Glove for Extravehicular Activity in Space” In: Adaptation Biology and Medicine, New Challenges, edited by LM Popescu, AR Hargens  and PK Singal, New Delhi, India: Narosa Publishing House, Vol. 7, pp.411-420, 2014. Chang DG, MA Padilla and AR Hargens. “Surface Electromyography: Technical Developments and Clinical Applications in Sports Medicine” In: Adaptation Biology and Medicine, New Challenges, edited by LM Popescu, AR Hargens and PK Singal, New Delhi, India: Narosa Publishing House, Vol. 7, pp.333-351, 2014. Morgan JL, Heer M, Hargens AR, Macias BR, Hudson EK, Shackelford LC, Zwart SR, and Smith SM. Sex-specific responses of bone metabolism and renal stone risk during bed rest. Physiological Reports 2014 Aug 7;2(8): 1-12, 2014. Bailey JF, Hargens AR, Cheng KK, and Lotz JC. Effect of microgravity on the biomechanical properties of lumbar and caudal intervertebral discs in mice. Journal of Biomechanics 47(12):2983-2988, 2014. Rosales-Velderrain A, Padilla M, Choe CH, and Hargens AR. Increased microvascular flow and foot sensation with mild continuous external compression. Physiological Reports 2013 Dec 19;1(7): 1-6, 2013. Shymon S, Hargens AR, Minkoff LA and Chang DG. Body posture and backpack loading: an upright magnetic resonance imaging study of the adult lumbar spine. European Spine Journal 23(7): 1407-1413, 2014. Hargens AR, Kim JM and Cao P. Accuracy of water displacement hand volumetry using an ethanol and water mixture. Aviation Space Environmental Medicine 85(2): 187-190, 2014. Zhang LF and Hargens AR. Intraocular/Intracranial pressure mismatch hypothesis for visual impairment syndrome in space. Aviation Space Environmental Medicine 85(1): 78-80, 2014. Lee SM, Schneider SM, Feiveson AH, Macias BR, Smith SM, Watenpaugh DE and Hargens AR. WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women. Journal of Applied Physiology 116(6):654-667, 2014. Kim SH, Oh JH, Lee OS, Lee HR and Hargens AR. Postoperative imaging of bioabsorbable anchors in rotator cuff repair. American Journal of Sports Medicine 42(3): 552-557, 2014. Shymon SJ, Yaszay B, Dwek JR, Proudfoot JA, Donohue M and Hargens AR. Altered disc compression in children with idiopathic low back pain: an upright magnetic resonance imagery backpack study. Spine 39: 243-248, 2014. Kim SH, Neuschwander TB, Macias BR, Bachman L Jr and Hargens AR. Upper extremity hemodynamics and sensation with backpack loads. Applied Ergonomics 45: 608-612, 2014. 2013 Lee SH, Padilla M, Lynch JE and Hargens AR. Noninvasive measurements of pressure for detecting compartment syndromes. Journal of Orthopedics and Rheumatology 1 (1): 1-15, 2013. Kraus EA, Kim JM and Hargens AR. Gravitational changes in hand-wrist volume are smaller in older adults as compared to younger adults. Journal of Cardiology and Vascular Medicine 1: 1-6, 2013. Rosales-Velderrain A, Padilla M, Choe CH and Hargens AR. Increased microvascular flow and foot sensation with mild continuous external compression. Physiological Reports 1(7): 1-6, 2013. Liu JH, Lynch JE, Rosales-Velderrain A, Chang DG, Weinreb RN and Hargens AR. Anterior-posterior transcranial ultrasound to measure cranial oscillations. Aviation Space Environmental Medicine 84: 995-1000, 2013. Kim SH, Glaser D, Doan J, Chung SW, Choi HY, Oh JH and Hargens AR. Loop securities of arthroscopic sliding-knot techniques when the suture loop is not evenly tensioned. Arthroscopy 29: 1380-1386, 2013. Zhang B, Cory E, Bhattacharya R, Sah R and Hargens AR. Fifteen days of microgravity causes growth in calvaria of mice. Bone 56(2): 290-295, 2013.   Schlabs T, Rosales-Velderrain A, Ruckstuhl H, Stahn AC and Hargens AR. Comparison of cardiovascular and biomechanical parameters of supine lower body negative pressure and upright lower body positive pressure to simulate          activity in 1/6 G and 3/8 G.  Journal of Applied Physiology 115(2): 275-284, 2013. Rodriguez-Soto AE, Jaworski R, Jensen A, Niederberger B, Hargens AR, Frank LR, Kelly KR and Ward SR. Effect of load carriage on lumbar spine kinematics. Spine 38: E783 – E791, 2013.  Mateus J and Hargens AR. Bone hemodynamic responses to changes in external pressure. Bone 52: 604-610, 2013. Hargens AR, Bhattacharya R and Schneider SM. Space Physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight. European Journal of Applied Physiology 113: 2183-2192, 2013. Goswami N, Batzel JJ, Clement G, Stein TP, Hargens AR, Sharp MK, Blaber AP, Roma PG, and Hinghofer-Szalkay HG. Maximizing information from space data resources: a case for expanding integration across research disciplines.         European Journal of Applied Physiology 113: 1645-1654, 2013. Sayson JV, Lotz J, Parazynski S and Hargens AR. Back pain in space and post-flight spine injury: Mechanisms and countermeasure development.  Acta Astronautica 86: 24-38, 2013. Kim SH, Crater RB and Hargens AR. Movement-induced knot migration after anterior stabilization in the shoulder. Arthroscopy 29(3): 485-490, 2013. 2012 Neuschwander TB, Macias BR, Hargens AR, and Zhang Q. Mild external compression of the leg increases skin and muscle microvascular blood flow and muscle oxygenation during simulated venous hypertension. ISRN Vascular Medicine, Volume 2012, Article ID 930913, pages 1-6. Macias BR, D’Lima DD, Cutuk A, Patil S, Steklov N, Neuschwander TB, Meuche S, Colwell CW and Hargens AR. Leg intramuscular pressures and in vivo knee forces during lower body positive and negative pressure treadmill exercise. Journal of Applied Physiology 113 (1): 31-38, 2012. Schmid-Schonbein GW and Hargens AR. “Mechanics of Tissue/Lymphatic Transport.” In: The Biomedical Engineering Handbook, 4th Edition, Biomedical Engineering Fundamentals, edited by JD Bronzino, Boca Raton, Florida: CRC Press LLC, in press, 2012. Mateus J and Hargens AR. Photoplethysmography for non-invasive in-vivo measurement of bone hemodynamics. Physiological Measurement 33:1027-1042, 2012. Macias BR, D’Lima DD, Cutuk A, Patil S, Steklov N, Neuschwander TB, Meduche S, Colwell CW, and Hargens AR. Leg intramuscular pressures and in vivo knee forces during lower body positive and negative pressure treadmill exercise. Journal of Applied Physiology, In press, 2012. Arbeille P, Shoemaker K, Kerbeci P, Schneider S, Hargens A, and Hughson R.  Aortic, cerebral and lower limb arterial and venous response to orthostatic stress after a 60-day bedrest. European Journal of Applied Physiology 112: 277-284, 2012.
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